課程資訊
課程名稱
 結構生物學概論
Introduction to Structural Biology 
開課學期
 108-1 
授課對象
 生命科學院  生化科技研究所  
授課教師
 楊啟伸 
課號
 BST5008 
課程識別碼
 B22EU0180 
班次
  
學分
 2.0 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期四6,7(13:20~15:10) 
上課地點
 農化二B10 
備註
 本課程以英語授課。碩士班A群組必修10學分課程之一。
總人數上限：80人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1081BST5008_ 
課程簡介影片
 
核心能力關聯
 本課程尚未建立核心能力關連
課程大綱
為確保您我的權利,請尊重智慧財產權及不得非法影印
課程概述

This is a class integrates the concepts of structural biology and bioinformatics. There are four major parts: 1) The basic principles of how 20 amino acids affect protein structures. 2) The modern methods currently adopted to resolve atomic resolution of protein structures will be explained. 3) Software tools for protein structure display and analysis, including PyMol, Swiss PDB viewer and UCSF Chimera, will be demonstrated. Several bioinformatics concepts and web servers will be mentioned in this class. 4) The mechanism behind protein structure and functional exertion will be emphasized and exercised via student presentations. 

課程目標
 1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of protein structural-related bioinformatics methods. 
課程要求
 This class will be taught in English. 
預期每週課後學習時數
  
Office Hours
 另約時間 備註： This class mainly does Q&A thorugh e-mail. 
指定閱讀
 Newly published journal articles. 
參考書目
 1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated according to new journal publications. 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Final Exam 
30% 
 Written Exam, Take-home/Open-book style 
2. 
 Personal Report 
20% 
 Protein structural analysis with software tools taught in this class 
3. 
 Presentation 
20% 
 Presentation of an assigned topic in Engilsh 
4. 
 Mid-term 
30% 
 Written Exam 
 
課程進度
週次
日期
單元主題
第1週
 9/12  <mark>1. Concepts of structural biology
2. What will be taught in this class</mark> 
第2週
 9/19  <mark>(Special Event)</mark> 
第3週
 9/26  <mark>Software tools
Amino Acids (1/2)</mark>
 
第4週
 10/03  <mark>Groups forming / assignment
Amino Acids (2/2) </mark> 
第5週
 10/10  <mark>Happy Birthday! Taiwan!</mark> 
第6週
 10/17  <mark>Amino Acids as Basic Elements In Protein Structure(1/2)
1. Amino Acids as Basic Elements In Protein Structure(2/2)
2. Five different basic structural elements: Alpha helix, Beta sheet, Beta turn, Beta bulge and Loop </mark> 
第7週
 10/24  <mark>1. Five major arrangements of protein structure
2. Functional Domains and motif
3. Protein Conformational Changes </mark> 
第8週
 10/31  <mark>Resolving protein structures (I):
1) X-ray diffraction (1/2): Crystal growing and Diffraction</mark> 
第9週
 11/07  <mark>1. Resolving protein structures (II):
X-ray diffraction (2/2)
2. NMR & CyroEM
3. Considerations of Protein Structural Resolving: Which Method to Use?</mark>
 
第10週
 11/14  <mark>Mid-term Exam (One week late than school schedule)</mark> 
第11週
 11/21  <mark>BYOC (Bring your own computer) day:
0. *** Form Groups for Presentation ***
1. Structure Resolving: A Review
2. All about PDB file
3. Let's play with those software to make movie! </mark> 
第12週
 11/28  <mark>Structural Biology & Bioinformatics
Prediction of 2nd Structure With Pen-and-paper <b><i>(unplug style)</b></I></mark> 
第13週
 12/05  <mark>Cellular proteins & Photosensory Systems</mark>
 
第14週
 12/12  <mark><b>[Group Presentation Week 1]</b> Structural Biology and Life Science:
1. Central dogma and cellular physiology
Group 1a and 1b
<b>[Group Presentation Week 2]</b> Structural Biology and Photobiology:
2. Photosensory system in all kind of life forms
Group 2a and 2b</mark>

Handout for this week was included in Lecture 11. 
第15週
 12/19  <mark><b>[Group Presentation Week 3]</b> Structural Biology and Life Science:
3. G-protein signaling and GPCR
Group 3a </mark> 
第16週
 12/26  <mark><b>[Group Presentation Week 4]</b> Structural Biology and Life Science:
4. Receptor & channels in the membrane (but not 2 and 3)
Group 4a and 4b</mark> 
第17週
 1/02  <mark><b>[Group Presentation Week 5]</b> Structural Biology and Life Science:
5. Signal transduction in two-component system
Group 5a and 5b</mark>